Everything about Dacarbazine totally explained
Dacarbazine (da-KAR-ba-zeen) (brand names DTIC, DTIC-Dome; also known as DIC or Imidazole Carboxamide) is an antineoplastic
chemotherapy drug used in the treatment of various cancers, among them
malignant melanoma and
Hodgkin lymphoma.
Antineoplastic drugs are drugs which interfere with cell growth and impede the formation of new tissue - in this case, tumor tissue. These drugs are also known as
cytotoxic drugs. Dacarbazine belongs to the family of chemicals known as
alkylating agents. Dacarbazine is normally administered by injection (a shot) or intravenous infusion (IV) under the immediate supervision of a doctor or nurse.
History
Dacarbazine gained FDA approval in May 1975 as DTIC-Dome. The drug was initially marketed by
Bayer.
Side effects
Like many chemotherapy drugs, dacarbazine may have numerous serious side effects, because it interferes with normal cell growth as well as cancer cell growth. Among the most serious possible side effects are birth defects to children conceived or carried during treatment; sterility, possibly permanent; or immune suppression (reduced ability to fight infection or disease). Dacarbazine is considered to be highly
emetogenic, and most patients will be pre-medicated with antiemetic drugs like
palonosetron or
aprepitant. Other significant side effects include headache, fatigue and occasionally diarrhea.
Common uses
As of mid-
2006, dacarbazine is commonly used as a single agent in the treatment of
metastatic melanoma, and as part of the
ABVD chemotherapy regimen to treat
Hodgkin lymphoma.
Experimental
Dacarbazine +
Oblimersen. In clinical trials for malignant
melanoma.
Suppliers
Bayer continues to supply DTIC-Dome. There are also generic versions of dacarbazine available from APP, Bedford, Mayne Pharma and Sicor (
Teva).
Further Information
Get more info on 'Dacarbazine'.
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